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Research collaboration is an important strategy to improve research output, and virtual academic communities (VACs) have become an important platform to collaborate on. This paper reveals the influencing factors of researchers’ collaboration intention in VACs from two attributes: individual, and inter-members. On the basis of the Social Cognitive Theory, Social Exchange Theory, social network theory, and Five-Factor Model, this paper constructed a model demonstrating the influencing factors of VACs researchers’ collaboration intention. A self-administered questionnaire was employed on members of four VACs in China to collect data; subsequently, 558 usable responses were analyzed using structural equation modeling. The result showed that openness, conscientiousness, reciprocity, trust, and the social network characteristic had a significant influence on the collaboration intention of researchers in VACs, while self-efficacy, agreeableness, extroversion, neuroticism, and experience had no significant effects on the collaboration intention of researchers in VACs. This model plays a positive role in promoting the research collaboration intention of Chinese VACs researchers and in guiding the construction of VAC platforms.