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Background: Dissociative disorder in adults is caused by traumatic life events. Various cultural backgrounds specify the multiple types of stressful or undesirable life events. Dissociative phenomena have a pervasive relationship with traumatic stress derived from any negative life event. The inability to cope with the stressors disrupted their behaviors or daily functioning beside that any traumatic life events considered a triggering factor of their mental illness. The interrelation between these two variables; coping mechanism and life event determine the treatment outcome, relapse rate, and prognosis of the dissociative disorder. Aim: The aim of this study is to compare the coping strategies and stressful life events between person with dissociative disorder and normal control group. Materials and Methods: Seventy respondents (35 of dissociative disorders and 35 of general population) were reviewed, and the two groups were compared with respect to their sociodemographic profile, life events, and coping mechanisms. Results: Respondents with dissociative disorders have experienced a higher number of stressful life events with dysfunctional coping mechanism. Conclusion: Stressful life events lead to develop dysfunctional coping pattern in the persons with dissociative disorder.