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The COVID-19 pandemic has led to the wide use of different disinfectants to reduce the spread of the virus in homes and public spaces. In particular, more chemical compounds are used in public places than they should be in order to control the epidemic in many parts of the world. However, with this practice, human health, biological diversity, and water resources can be adversely affected. Therefore, the possible effects of chemicals used for cleaning and hygiene purposes should be evaluated in an integrated manner. The chemicals effective in deactivating the virus and their possible environmental effects were explored in this article.