Super-enhancer-guided mapping of regulatory networks controlling mouse trophoblast stem cells
oleh: Bum-Kyu Lee, Yu jin Jang, Mijeong Kim, Lucy LeBlanc, Catherine Rhee, Jiwoon Lee, Samuel Beck, Wenwen Shen, Jonghwan Kim
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-10-01 |
Deskripsi
Trophectoderm lineage development is essential for implantation, placentation, and healthy pregnancy. Here the authors map super-enhancers (SEs) in trophoblast stem cells and find both TE-specific master regulators and 150 previous uncharacterised transcription factors that are SE-associated, providing insight into trophectoderm-specific regulatory networks.