Magnetically recyclable CuFe2O4 catalyst for efficient synthesis of bis(indolyl)methanes using indoles and alcohols under mild condition
oleh: Ngoc-Khanh Nguyen, Minh-Tuan Ha, Hoang Yen Bui, Quang Thang Trinh, Bich Ngoc Tran, Van Tuyen Nguyen, Tran Quang Hung, Tuan Thanh Dang, Xuan Hoan Vu
| Format: | Article |
|---|---|
| Diterbitkan: | Elsevier 2021-01-01 |
Deskripsi
Bis(3-indolyl)methanes (BIM) are highly valuable and appear in the core structure of many natural products and pharmacologically active compounds (anticancer, anti-inflammatory, antiobesity, antimetastatic, antimicrobial, etc.). Herein, we have disclosed an air stable and highly efficient CuFe2O4 heterogeneous catalyst for alkylation of indoles with alcohols to give bis(3-indolyl)methanes in very good yields. The CuFe2O4 catalyst has been found to be magnetically recycled at least five times without losing significant catalytic activity.