A robust and efficient method for Mendelian randomization with hundreds of genetic variants
oleh: Stephen Burgess, Christopher N Foley, Elias Allara, James R Staley, Joanna M. M. Howson
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-01-01 |
Deskripsi
Mendelian randomization (MR) is a method for inferring causal relationships between risk factors and outcomes via associated genetic variants. Here, Burgess et al. develop the contamination mixture method which yields robust MR results in the presence of invalid instrumental variables and groups variants by their effect estimates.