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<em>BRCA</em> Genes and Related Cancers: A Meta-Analysis from Epidemiological Cohort Studies
oleh: Yen-Chien Lee, Yen-Ling Lee, Chung-Yi Li
Format: | Article |
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Diterbitkan: | MDPI AG 2021-08-01 |
Deskripsi
<i>Background and Objectives:</i><i>BRCA1</i> and <i>BRCA2</i> are genes located in different chromosomes that are disproportionately associated with hereditary breast and ovarian cancer syndrome. Their association with other cancers remains to be explored. <i>Materials and Methods:</i> We systematically reviewed cohort studies to explore the association of <i>BRCA 1</i> and <i>BRCA2</i> with various cancers except lung cancer. We searched PubMed, Medline (EBSCOhost) and relevant articles published up to 10 May 2021. The odds ratio, standardised morbidity rate and cancer-specific standardised incidence ratio were pooled together as relative risk (RR) estimates. <i>Results:</i> Twelve studies were included for analysis. <i>BRCA</i> mutation increased pancreatic and uterine cancers by around 3–5- and 1.5-fold, respectively. <i>BRCA</i> mutation did not increase brain cancer; colorectal cancer; prostate, bladder and kidney cancer; cervical cancer; or malignant melanoma. <i>BRCA2</i> increased gastric cancer with RR = 2.15 (1.98–2.33). <i>Conclusion:</i> The meta-analysis results can provide clinicians and relevant families with information regarding increased specific cancer risk in <i>BRCA1</i> and <i>BRCA2</i> mutation carriers.