Synthesis of New 1,2,3-Triazol-4-yl-quinazoline Nucleoside and Acyclonucleoside Analogues
oleh: Abdelaaziz Ouahrouch, Moha Taourirte, Joachim W. Engels, Soumaya Benjelloun, Hassan B. Lazrek
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2014-03-01 |
Deskripsi
In this study, we describe the synthesis of 1,4-disustituted-1,2,3-triazolo-quinazoline ribonucleosides or acyclonucleosides by means of 1,3-dipolar cycloaddition between various O or N-alkylated propargyl-quinazoline and 1'-azido-2',3',5'-tri-O-benzoylribose or activated alkylating agents under microwave conditions. None of the compounds selected showed significant anti-HCV activity in vitro.