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The effect of Saccharomyces cerevisiae (SC) in counteracting the toxicity of aflatoxin in broilers was studied. Aflatoxin (1 ppm) caused significant (P < 0.05) reduction in the serum concentration of total protein, albumin, cholesterol and glucose and in eviscerated carcass yield. Relative weights of the gizzard and heart did not differ significantly (P < 0.05) among different treatments. Relative weights of the liver, kidney and proventriculus increased significantly (P < 0.05) during aflatoxicosis. SC counteracted the toxic effects of aflatoxin on the serum biochemistry and relative weights of the liver and kidney. However, eviscerated carcass yield and relative weight of the proventriculus remained unchanged with the addition of SC.