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The human papillomavirus (HPV) is certainly one of the few viruses associated with cancer and is present in a significant number of cancers of the anus, penis, vagina, vulva and in almost all cervical cancers.The aim of our work is to evaluate the impact of genotypes high-risk oncogenic (HR) in low-grade (LSIL) and high grade (HSIL) intraepithelial lesions. In it are also evaluated the impact of genotypes low oncogenic risk (LR) and the percentage of non-detection (NR) Papillomavirus DNA Between January 2008 and June 2009 we submitted for HPV DNA genotyping test 392 patients, seronegative for HIV1/2, of which 278 with LSIL and 114 with HSIL. In 250 patients tested positive for HPV DNA HR the type 16 is present in 102 patients (41%), the 18 in 62 (25%), the 31 in 37 patients (15%), the 33 in 13 patients (5%); also was limited the simultaneous presence of 16 and 18 (13 patients 5%) The search for HPV DNA is a modern method of study of cervical pathology. Optimizes the follow-up of intraepithelial lesions and the therapeutic intervention, avoiding the dangers of over/ undertreatment and allows to monitor women treated for cervical pathology.