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Zn(II) and Cd(II) complexes of a Schiff base derived from quinazoline-4(3H) one and 2-formylphenoxy acetic acid were prepared and characterized by elemental and different spectroscopic (IR, UV-Visible and NMR) analyses. The elemental analysis indicated the formation of the complexes: [ML(AcO)].H2O, where M stands for Zn(II) and Cd(II) and L stands for quinazoline-4(3H)-one Schiff base. The molar conductivities of the prepared complexes revealed their non-electrolytic nature. The complexes were also investigated for their antimicrobial activities by using turbidometric assay method.