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Stem cells (SCs) have an ultimate potential of regenerating tissues and organs due to their salient properties. In the contemporary years, emergence of novel tissue bioengineering therapies and gene editing technologies has been a breakthrough in the field of SC research. A combination of these paradigm-shifting technologies with dental SCs definitely has brighter prospects in the upcoming decades. The goal of the current study of literature is to highlight the latest technologies and regenerative applications of SCs in the field of dentistry.