Modulatory mechanisms of TARP γ8-selective AMPA receptor therapeutics
oleh: Danyang Zhang, Remigijus Lape, Saher A. Shaikh, Bianka K. Kohegyi, Jake F. Watson, Ondrej Cais, Terunaga Nakagawa, Ingo H. Greger
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2023-03-01 |
Deskripsi
AMPA receptors associated with TARP subunits enable the development of selective AMPA receptor drugs. Here, the authors provide cryo-EM structures of receptors bound to three TARP-γ8 selective drugs, and reveal bifunctionality of one ligand.