Clinical transplantation using negative pressure ventilation ex situ lung perfusion with extended criteria donor lungs
oleh: Max T. Buchko, Nasim Boroumand, Jeffrey C. Cheng, Alim Hirji, Kieran Halloran, Darren H. Freed, Jayan Nagendran
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-11-01 |
Deskripsi
Preclinical studies have shown that negative pressure ventilation ex situ lung perfusion results in less ventilator-induced lung injury compared to positive pressure ventilation of donor lungs during transplantation procedures. Here the authors perform a single-arm clinical trial with 12 participants to study patient survival and primary graft dysfunction with ex situ lung perfusion.