The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells
oleh: Kazuhito Naka, Ryosuke Ochiai, Eriko Matsubara, Chie Kondo, Kyung-Min Yang, Takayuki Hoshii, Masatake Araki, Kimi Araki, Yusuke Sotomaru, Ko Sasaki, Kinuko Mitani, Dong-Wook Kim, Akira Ooshima, Seong-Jin Kim
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-09-01 |
Deskripsi
How lipid metabolism can affect cancer recurrence is still unclear. Here, the authors show that the lysophospholipase D Gdpd3 maintains self-renewal capacity of CML stem cells by regulating the quiescence, and AKT/mTORC1 and Foxo3a/β-catenin signalling in an oncogene-independent manner.