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The milky sap or latex of <i> Euphorbia</i> plant is highly toxic and an irritant to the skin and eye. This report illustrates the spectrum of ocular inflammation caused by accidental inoculation of latex of <i> Euphorbia</i> plant. Three patients presented with accidental ocular exposure to the milky sap of <i> Euphorbia</i> species of recent onset. The initial symptoms in all cases were severe burning sensation with blurring of vision. Visual acuity reduced from 20/60 to counting fingers. Clinical findings varied from kerato-conjunctivitis, mild to severe corneal edema, epithelial defects, anterior uveitis and secondary elevated intraocular pressure. All symptoms and signs had resolved by 10-14 days with active supportive medication. People who handle <i> Euphorbia </i> plants should wear eye protection. It is always advisable to ask the patient to bring a sample of the plant for identification.