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Antimicrobial resistance (AMR), also known as antibiotic resistance, is a global health crisis. Many people die from diseases caused by multi-drug resistant pathogens (MDR). Artificial intelligence (AI) deals with applying theory and developing computer systems to conduct tasks usually requiring human intelligence, such as visual perception, speech recognition, decision-making, and translation between languages to solve problems. AI has been successfully used in various fields, from single-cell study to space science. There is huge potential for using AI in medical science, including fighting against MDR to combat AMR. In this review, we have highlighted some of AI's successful uses and potentiality to combat AMR for the betterment of the human race, including the basic principles of AI, available AI resources, use and scope, advantages and limitations. [ J Adv Biotechnol Exp Ther 2023; 6(3.000): 711-727]