Generation of integration-free induced pluripotent stem cells from healthy individuals
oleh: Cristine Marie Yde Ohki, Leoni Grossmann, Christian Döring, Per Hoffmann, Stefan Herms, Anna Maria Werling, Susanne Walitza, Edna Grünblatt
| Format: | Article |
|---|---|
| Diterbitkan: | Elsevier 2021-05-01 |
Deskripsi
Ten human induced pluripotent stem cell (iPSC) lines have been derived from five healthy controls matched to a study including Attention-Deficit Hyperactivity Disorder patients (ADHD). Both female and male children and adolescents aged 6–18 years were recruited. Isolated keratinocyte cells from the participants were reprogrammed into iPSCs using non-integrating Sendai virus to deliver the reprogramming factors Oct3/4, Sox2, Klf4 and cMyc.