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By irnmunocdiffusion tests 312 serum samples from human were examined for the presence of antibodies to the group.reactive precipitatng antigen of adenoviruses. of the total sera from female, 19.6% and from male, 15.8% had antibody to the group reactive antigen prepared from bovine adenovirus type 3. No significant difference was demo., nstrated on account of sex or age. The results suggest that adenovirus infection is widespread among the human population in Iran.