Copper-catalyzed enantioselective Sonogashira-type oxidative cross-coupling of unactivated C(sp 3)−H bonds with alkynes
oleh: Zhen-Hua Zhang, Xiao-Yang Dong, Xuan-Yi Du, Qiang-Shuai Gu, Zhong-Liang Li, Xin-Yuan Liu
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-12-01 |
Deskripsi
Enantioselective oxidative cross-coupling of unactivated C(sp 3)−H bonds and terminal alkynes is challenging. Here, the authors developed a copper/cinchona alkaloid catalyst for the asymmetric Sonogashira-type alkynylation of C(sp 3)-H bonds via radical intermediates.