Next-generation transgenic mice for optogenetic analysis of neural circuits
oleh: Brent eAsrican, George J eAugustine, George J eAugustine, George J eAugustine, George J eAugustine, George J eAugustine, George J eAugustine, George J eAugustine, Ken eBerglund, Susu eChen, Susu eChen, Susu eChen, Nicholas eChow, Nicholas eChow, Karl eDeisseroth, Guoping eFeng, Bernd eGloss, Riichiro eHira, Riichiro eHira, Riichiro eHira, Carolin eHoffmann, Carolin eHoffmann, Haruo eKasai, Malvika eKatarya, Malvika eKatarya, Jinsook eKim, Jinsook eKim, Jinsook eKim, John eKudolo, Liming eLee, Liming eLee, Shun-Qiang eLo, Shun-Qiang eLo, Shun-Qiang eLo, James eMancuso, James eMancuso, Masanori eMatsuzaki, Masanori eMatsuzaki, Masanori eMatsuzaki, Ryuichi eNakajima, Li eQui, Gregory eTan, Gregory eTan, Yanxia eTang, Yanxia eTang, Jonathan T. eTing, Jonathan T. eTing, Sachiko eTsuda, Sachiko eTsuda, Lei eWen, Xuying eZhang, Shengli eZhao
| Format: | Article |
|---|---|
| Diterbitkan: | Frontiers Media S.A. 2013-11-01 |
Deskripsi
Here we characterize several new lines of transgenic mice useful for optogenetic analysis of brain circuit function. These mice express optogenetic probes, such as enhanced halorhodopsin or several different versions of channelrhodopsins, behind various neuron-specific promoters. These mice permit photoinhibition or photostimulation both in vitro and in vivo. Our results also reveal the important influence of fluorescent tags on optogenetic probe expression and function in transgenic mice.