CAR T cells redirected to cell surface GRP78 display robust anti-acute myeloid leukemia activity and do not target hematopoietic progenitor cells
oleh: Nikhil Hebbar, Rebecca Epperly, Abishek Vaidya, Unmesha Thanekar, Sarah E. Moore, Masayuki Umeda, Jing Ma, Sagar L. Patil, Deanna Langfitt, Sujuan Huang, Cheng Cheng, Jeffery M. Klco, Stephen Gottschalk, M. Paulina Velasquez
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-01-01 |
Deskripsi
There is an unmet need to discover suitable targets for CAR-T therapy in patients with acute myeloid leukemia (AML). Here the authors show that GRP78, a key regulator of the unfolded protein response, is highly expressed on the surface of primary AML blasts, but not on normal lymphocytes and hematopoietic progenitor cells, and that GRP78-CAR T have anti-AML activity in preclinical models.