Pathological Characteristics of Domestic Pigs Orally Infected with the Virus Strain Causing the First Reported African Swine Fever Outbreaks in Vietnam
oleh: Thi Thu Huyen Nguyen, Van Tam Nguyen, Phuong Nam Le, Nguyen Tuan Anh Mai, Van Hieu Dong, Tran Anh Dao Bui, Thi Lan Nguyen, Aruna Ambagala, Van Phan Le
| Format: | Article |
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| Diterbitkan: | MDPI AG 2023-03-01 |
Deskripsi
African swine fever (ASF) is currently Vietnam’s most economically significant swine disease. The first ASF outbreak in Vietnam was reported in February 2019. In this study, VNUA/HY/ASF1 strain isolated from the first ASF outbreak was used to infect 10 eight-week-old pigs orally with 10<sup>3</sup> HAD<sub>50</sub> per animal. The pigs were observed daily for clinical signs, and whole blood samples were collected from each animal for viremia detection. Dead pigs were subjected to full post-mortem analyses. All 10 pigs displayed acute or subacute clinical signs and succumbed to the infection between 10 to 27 (19.8 ± 4.66) days post-inoculation (dpi). The onset of clinical signs started around 4–14 dpi. Viremia was observed in pigs from 6–16 dpi (11.2 ± 3.55). Enlarged, hyperemic, and hemorrhagic lymph nodes, enlarged spleen, pneumonia, and hydropericardium were observed at post-mortem examinations.