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Abstract Background: the proper zinc and copper levels seem very important to our immune system. Because of association of copper and zinc in many enzymes structures, and also the important role of them in the immune system most of the evaluations have considered both copper and zinc together.Objective: evaluate serum copper and zinc levels in children suffering from pneumonia and its relation to CD34+ cell.Study design: 37 patients (21 males and 16 females)with proven diagnosis of pneumoniathese patients were selected as one every three cases admitted to chest unit of Pediatric Department, Zagazig University Hospital during the year 2012,their ages ranging from 6 months to 5 years and 37 healthy children(19 males and 18 females) were studied as control group.Results: WBCs, platelets, CRP, ESR, neutrophils and lymphocytes were highly significantly higher in patients than controls while hemoglobin, zinc, copper, CD34+ levels were highly significantly lower. There were highly significant positive correlation between CD34 and both copper and zinc levels.Conclusion: Low serum copper and zinc levels may be a contributing factor to the pathophysiology of community acquired pneumonia through its effect on the immune system.