Adipocytes promote malignant growth of breast tumours with monocarboxylate transporter 2 expression via β-hydroxybutyrate
oleh: Chun-Kai Huang, Po-Hao Chang, Wen-Hung Kuo, Chi-Long Chen, Yung-Ming Jeng, King-Jen Chang, Jin-Yuh Shew, Chun-Mei Hu, Wen-Hwa Lee
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-03-01 |
Deskripsi
Invasion of the adipose tissue correlates with poor prognosis in breast cancer. Here, the authors show that mammary gland adipocytes promote malignancy via β-hydroxybutyrate, which acts on cancer cells through the monocarboxylate transporter MCT2 resulting in tumour-promoting epigenetic modifications.