Structural basis of template strand deoxyuridine promoter recognition by a viral RNA polymerase

oleh: Alec Fraser, Maria L. Sokolova, Arina V. Drobysheva, Julia V. Gordeeva, Sergei Borukhov, John Jumper, Konstantin V. Severinov, Petr G. Leiman

Format: Article
Diterbitkan: Nature Portfolio 2022-06-01

Deskripsi

Promoter recognition is a critical step in the initiation of transcription of DNA to RNA. Here, the authors describe a novel mechanism by which a phage-encoded RNA polymerase recognizes viral promoters containing deoxyuridines instead of thymidines.