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Annual influenza vaccination is the best means of prevention and control of influenza virus infection and its complications. Efforts to increase influenza vaccines coverage, especially in high-risk groups including young children, the elderly, pregnant women and immunocompromised individuals have led to substantial reduction in health burden, severity and duration of infection. This review will focus on vaccination coverage against influenza infection among different population groups in Iran. Also, available evidence suggesting the effectiveness and adverse effects of currently licensed influenza vaccines will be discussed.