NF-Y controls fidelity of transcription initiation at gene promoters through maintenance of the nucleosome-depleted region
oleh: Andrew J. Oldfield, Telmo Henriques, Dhirendra Kumar, Adam B. Burkholder, Senthilkumar Cinghu, Damien Paulet, Brian D. Bennett, Pengyi Yang, Benjamin S. Scruggs, Christopher A. Lavender, Eric Rivals, Karen Adelman, Raja Jothi
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-07-01 |
Deskripsi
The mechanisms underlying specific TSS selection in mammals remain unclear. Here the authors show that the ubiquitously expressed transcription factor NF-Y regulate fidelity of transcription initiation at gene promoters, maintaining the region upstream of TSSs in a nucleosome-depleted state, while protecting this region from ectopic transcription initiation.