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There is a major need for novel therapies in depression. One that has been suggested is transcranial direct current stimulation (tDCS), a form of mild, non-invasive electrical brain stimulation tDCS has been used effectively as an intervention for major depression, both alone and as an augmentative therapy combined with antidepressant medication Few studies have explored the neural mechanisms underlying the putative antidepressant effect of tDCS An improved understanding of the mechanisms underlying the antidepressant effect of tDCS is vital for enhancing clinical efficacy and predicting response to treatment, but this technique shows great potential as a safe, effective, and cost-effective therapy