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Background and Aims: In recent years, the dentistry workflow has developed considerably. By the introduction of computers and their various applications, the effectiveness and efficiency of treatment has increased enormously. Considering engineering concepts in the workflow, it is necessary for participants to assess different steps and data transferring between various software and hardware devices. This research investigated the interaction between dentists, laboratories and production centers through the required steps for accomplishing treatment by different applications of software and digital hardware devices. Materials and Methods: Review in this article was based on searching Google scholar database considering key words: digital dentistry, workflow, computer aided design and manufacturing, dental CAD/CAM. This search was limited to the English articles published after the year 2000. Conclusion: It is necessary in dentistry to use digital technologies to improve the efficiency of treatments. Thus, the participants in this field must have appropriate knowledge to choose and apply these tools. Moreover, the participant should help providers of digital solutions for better development of software packages and related hardwares.a