Dusp6 inhibits epithelial-mesenchymal transition in endometrial adenocarcinoma via ERK signaling pathway
oleh: Fan Ming-Jun, Liang Shu-Mei, He Peng-Juan, Zhao Xing-Bo, Li Ming-Jiang, Geng Feng
| Format: | Article |
|---|---|
| Diterbitkan: | Sciendo 2019-09-01 |
Deskripsi
Endometrial adenocarcinoma (EAC) is one of the most commonly diagnosed gynaecological malignancies among female population of the developed countries. DUSP6 is a negative regulator of ERK signaling, which is a molecular switch involved in MAPK signaling during the progress of malignancies. DUSP6 was previously found to inhibit tumorigenesis and EMT-associated properties in several cancers, however, its exact role in EAC remains unclear