RNA structure-wide discovery of functional interactions with multiplexed RNA motif library

oleh: Kaoru R. Komatsu, Toshiki Taya, Sora Matsumoto, Emi Miyashita, Shunnichi Kashida, Hirohide Saito

Format: Article
Diterbitkan: Nature Portfolio 2020-12-01

Deskripsi

Structured RNA motifs can be obtained by structure probing, duplex capture, and motif prediction. Here the authors develop a multiplexed affinity assay system to identify functional protein interactors from an RNA structure library with validated or predicted RNA motifs.