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This paper introduces a parallel meta-heuristic algorithm called Cuckoo Flower Search (CFS). This algorithm combines the Flower Pollination Algorithm (FPA) and Cuckoo Search (CS) to train Multi-Layer Perceptron (MLP) models. The algorithm is evaluated on standard benchmark problems and its competitiveness is demonstrated against other state-of-the-art algorithms. Multiple datasets are utilized to assess the performance of CFS for MLP training. The experimental results are compared with various algorithms such as Genetic Algorithm (GA), Grey Wolf Optimization (GWO), Particle Swarm Optimization (PSO), Evolutionary Search (ES), Ant Colony Optimization (ACO), and Population-based Incremental Learning (PBIL). Statistical tests are conducted to validate the superiority of the CFS algorithm in finding global optimum solutions. The results indicate that CFS achieves significantly better outcomes with a higher convergence rate when compared to the other algorithms tested. This highlights the effectiveness of CFS in solving MLP optimization problems and its potential as a competitive algorithm in the field.