Five New Cucurbitane-Type Triterpenoid Glycosides from the Rhizomes of <i>Hemsleya penxianensis</i> with Cytotoxic Activities
oleh: De-Li Chen, Xu-Dong Xu, Rong-Tao Li, Bo-Wen Wang, Meng Yu, Yang-Yang Liu, Guo-Xu Ma
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2019-08-01 |
Deskripsi
Five new cucurbitane-typetriterpenoid glycosides, named Xuedanoside F−J (<b>1</b>−<b>5</b>), were obtained from the rhizomes of <i>Hemsleya penxianensis</i> (Xue dan), which belongs to the family of Cucurbitaceae. These new compounds were elucidated byspectroscopic analysis, including 1D, 2D NMR, and HR-ESI-MS spectra. Additionally, all the isolates were evaluated for cytotoxicity against three human cancer cell lines (Hela, MCF-7, and A-549) with the IC<sub>50</sub> ranging from 2.25 to 49.44 µM in vitro with treatment 48 h and showed low cytotoxicity in human normal liver L-02 cells (IC<sub>50</sub> > 50 µM). Compound <b>5</b> showed the most significant cytotoxic activity with the IC<sub>50</sub> value of 2.25, 4.72, and 5.33 µM in 48 h, respectively.