Activation of von Willebrand factor via mechanical unfolding of its discontinuous autoinhibitory module
oleh: Nicholas A. Arce, Wenpeng Cao, Alexander K. Brown, Emily R. Legan, Moriah S. Wilson, Emma-Ruoqi Xu, Michael C. Berndt, Jonas Emsley, X. Frank Zhang, Renhao Li
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-04-01 |
Deskripsi
Von Willebrand factor (VWF) is a large glycoprotein in the blood secreted from endothelial cells lining the blood vessel and activation of VWF leads to formation of VWF-platelet complexes or thrombi. Here authors use single-molecule force measurement, X-ray crystallography and functional measurements to monitor the activation of VWF via mechanical unfolding of the autoinhibitory module (AIM).