Hedgehog is relayed through dynamic heparan sulfate interactions to shape its gradient
oleh: Fabian Gude, Jurij Froese, Dominique Manikowski, Daniele Di Iorio, Jean-Noël Grad, Seraphine Wegner, Daniel Hoffmann, Melissa Kennedy, Ralf P. Richter, Georg Steffes, Kay Grobe
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2023-02-01 |
Deskripsi
The Hedgehog morphogen creates gradients during development, but diffusion alone cannot explain its spatiotemporal dynamics. Hedgehog transport requires binding heparan sulfate sugar chains, and the authors now show that Hedgehogs can spread by interacting with sequential heparan molecules.