Synthesis of nanoparticle CT contrast agents: in vitro and in vivo studies
oleh: Sung June Kim, Wenlong Xu, Md Wasi Ahmad, Jong Su Baeck, Yongmin Chang, Ji Eun Bae, Kwon Seok Chae, Tae Jeong Kim, Ji Ae Park, Gang Ho Lee
| Format: | Article |
|---|---|
| Diterbitkan: | Taylor & Francis Group 2015-10-01 |
Deskripsi
Water-soluble and biocompatible D-glucuronic acid coated Na2WO4 and BaCO3 nanoparticles were synthesized for the first time to be used as x-ray computed tomography (CT) contrast agents. Their average particle diameters were 3.2 ± 0.1 and 2.8 ± 0.1 nm for D-glucuronic acid coated Na2WO4 and BaCO3 nanoparticles, respectively. All the nanoparticles exhibited a strong x-ray attenuation. In vivo CT images were obtained after intravenous injection of an aqueous sample suspension of D-glucuronic acid coated Na2WO4 nanoparticles, and positive contrast enhancements in the kidney were clearly shown. These findings indicate that the nanoparticles reported in this study may be promising CT contrast agents.