Active viral shedding in a vaccinated hospitalized patient infected with the delta variant (B.1.617.2) of SARS-CoV-2 and challenges of de-isolation
oleh: Abeer N. Alshukairi, Awad Al-Omari, Jaffar A. Al-Tawfiq, Sherif A. El-Kafrawy, Mai M. El-Daly, Ahmed M. Hassan, Arwa A. Faizo, Thamir A. Alandijany, Ashraf Dada, Mohammed F. Saeedi, Fatma S. Alhamlan, Mohammad K. Al Hroub, Ismael Qushmaq, Esam I. Azhar
| Format: | Article |
|---|---|
| Diterbitkan: | Elsevier 2022-06-01 |
Deskripsi
In the era of SARS-CoV-2 variants and COVID-19 vaccination, the duration of infectious viral shedding and isolation in post vaccine breakthrough infections is challenging and depends on disease severity. The current study described a case of SARS-CoV-2 Delta variant pneumonia requiring hospitalization. The patient received two doses of BNT162b2 COVID-19 vaccines, and he had positive SARS-CoV-2 viral cultures 12 days post symptom onset. The time between the second dose of vaccine and the breakthrough infection was 6 months. While immunosuppression is a known risk factor for prolonged infectious viral shedding, age and time between vaccination and breakthrough infection are important risk factors that warrant further studies.