Identification of highly potent α-glucosidase inhibitors from Garcinia schomburgkiana and molecular docking studies
oleh: Thi My Lien Do, Nguyen-Minh-An Tran, Thuc-Huy Duong, Preecha Phuwapraisirisan, Nakorn Niamnont, Kewalin Inthanon, Jirapast Sichaem, Suttira Sedlak
| Format: | Article |
|---|---|
| Diterbitkan: | Prince of Songkla University 2021-12-01 |
Deskripsi
Twenty-two compounds (1-22) were isolated from the stems and twigs of Garcinia schomburgkiana. NMR, IR, UV, and MS were used for structural elucidation, and comparisons were made with previous reports. Compound 1 exhibited the most potent α-glucosidase inhibition (IC50 0.31 ± 0.7 μM), outperforming the positive control (acarbose). Molecular docking results showed that the phenolic hydroxyl groups on the phenyl rings linked with active receptor sites on the protein in 1. By preventing the duplication of DNA sequences, Compound 1 is an excellent inhibitor of the α-glucosidase enzyme, and represents a potential novel class of α-glucosidase inhibitor.