Metabolic reprogramming by Zika virus provokes inflammation in human placenta
oleh: Qian Chen, Jordi Gouilly, Yann J. Ferrat, Ana Espino, Quentin Glaziou, Géraldine Cartron, Hicham El Costa, Reem Al-Daccak, Nabila Jabrane-Ferrat
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-06-01 |
Deskripsi
Zika virus (ZIKV) infection of pregnant women is associated with pregnancy loss and birth defects, but molecular insights for the aetiology are scarce. Here the authors show that ZIKV reprograms the host lipidome to facilitate viral replication, induce mitochondria dysfunction, and cause immune imbalance, thereby identifying a potential target for ZIKV therapy.