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Fungal endophytes are a significant reservoir of novel bioactive secondary metabolites. Present communication describes isolation and structure determination of isochromenone, from endophytic microorganism <em>Aspergillus</em> <em>fumigatus</em> hosted in <em>Bacopa</em> <em>monnieri</em> plant. Further, its biological evaluation revealed it as antioxidant and antitubercular. The methanol extract of <em>A</em>. <em>fumigatus</em> inhibits the growth of the virulent strain of <em>Mycobacterium</em> <em>tuberculosis</em> H37RV with minimum inhibitory concentration 500 μg/mL. This is the first report of isolation of isochromenone from <em>A. fumigatus.</em>