Altilix<sup>®</sup> Supplement Containing Chlorogenic Acid and Luteolin Improved Hepatic and Cardiometabolic Parameters in Subjects with Metabolic Syndrome: A 6 Month Randomized, Double-Blind, Placebo-Controlled Study
oleh: Giuseppa Castellino, Dragana Nikolic, Antonio Magán-Fernández, Giuseppe Antonio Malfa, Roberta Chianetta, Angelo M. Patti, Antonella Amato, Giuseppe Montalto, Peter P. Toth, Maciej Banach, Arrigo F. G. Cicero, Manfredi Rizzo
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2019-10-01 |
Deskripsi
The objective was to evaluate the effects of 6 months of supplementation with Altilix<sup>®</sup>, containing chlorogenic acid and its derivatives, and luteolin and its derivatives, on cardiovascular risk and hepatic markers in subjects with metabolic syndrome (MetS). A randomized, double-blind, placebo-controlled study was performed in 100 subjects with MetS with a follow-up period of 6 months; 50 subjects were randomized to Altilix<sup>®</sup> (26 men and 24 women, mean age 63 ± 8 years) and the other 50 to placebo (28 men and 22 women, mean age 63 ± 11 years). Anthropometric, cardiometabolic, and hepatic parameters were assessed at baseline and at the end of follow-up. Carotid intima-media thickness and endothelial function were assessed by doppler ultrasound and by flow-mediated dilation of the brachial artery, respectively. The presence and degree of non-alcoholic fatty liver disease (NAFLD) was assessed by the fatty liver index (FLI), and subjects were divided into three subgroups: (1) without NAFLD; (2) with borderline NAFLD; and (3) with NAFLD. After 6 months of Altilix<sup>®</sup> supplementation, we found a significant improvement vs. placebo in most of the evaluated parameters, including body weight (−2.40% (95% CI −3.79, −1.01); <i>p</i> < 0.001), waist circumference (−2.76% (95% CI −4.55, −0.96); <i>p</i> = 0.003), HbA1c (−0.95% (95% CI −1.22, −0.67); <i>p</i> < 0.001), plasma lipids, FLI (−21.83% (95% CI −27.39, −16.27); <i>p</i> < 0.001), hepatic transaminases, flow-mediated dilation (10.56% (95% CI 5.00, 16.12); <i>p</i> < 0.001), and carotid intima-media thickness (−39.48% (95% CI −47.98, −30.97); <i>p</i> < 0.001). Further, the improvement in cardiometabolic variables was independent of the degree of hepatic steatosis. Altilix<sup>®</sup> supplementation improved hepatic and cardio-metabolic parameters in MetS subjects. Altilix<sup>®</sup> supplementation was a beneficial approach in the management of hepatic and cardiometabolic alterations in MetS subjects.