Facile and Stereoselective Synthesis of Non-Racemic 3,3,3-Trifluoroalanine

oleh: Matteo Zanda, Alessandro Volonterio, Pierfrancesco Bravo, Natalia Battista, Marcello Crucianelli

Format: Article
Diterbitkan: MDPI AG 2000-12-01

Deskripsi

A highly stereoselective enantiodivergent synthesis of non-racemic 3,3,3-trifluoroalanine 7 is reported. The methodology is based on the reduction, by 9-BBN or DIBAH, of the chiral sulfinimine 3 derived from ethyl trifluoropyruvate, followed by acidic hydrolysis of the resulting diastereomeric sulfinamides 4 and 5.