The hexokinase “HKDC1” interaction with the mitochondria is essential for liver cancer progression
oleh: Md. Wasim Khan, Alexander R. Terry, Medha Priyadarshini, Vladimir Ilievski, Zeenat Farooq, Grace Guzman, Jose Cordoba-Chacon, Issam Ben-Sahra, Barton Wicksteed, Brian T. Layden
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Publishing Group 2022-07-01 |
Deskripsi
Mitochondrial interaction of HKDC1 is essential for its pro-proliferative role in LC. When HKDC1 is ablated in liver cancer cells, mitochondrial dysfunction occurs which results in decrease ATP in the cells. The cancer cells react to decreased cellular energy by increasing glucose uptake. Also due to mitochondrial dysfunction there is enhanced ER stress and ER-mitochondrial interaction, leading to more calcium flux into the mitochondria. This multi-pronged effects of HKDC1 ablation leads to decreased cellular proliferation in LC.