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The present study aimed to assess the effect of an educational intervention about cardiorespiratory arrest in the theoretical knowledge of nursing professionals in medical-surgical hospitalization units. This is a quasi-experimental study, developed with professionals working in two admission units from a public university hospital in Paraná state. As an educational intervention, we conducted theoretical-practical training. We applied a questionnaire before and after training. We considered p values <0.05 as significant. Of the 47 professionals who worked in these units, 37 (78.72%) participated in the pre-test and, 32 (68.09%) in the post-test. We identified a female prevalence, aged between 31 and 45 years, who worked in their unit and had more than five years of professional training. The scores obtained after the educational intervention (post-test) was statistically significant (p<0.0001), in comparison to the pre-test. The educational intervention positively collaborated with the theoretical knowledge of nursing professionals about cardiorespiratory arrest.