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Aim:Various factors including free oxygen radicals were have been described in the pathogenesis of inflammatory bowel disease. The aim of this study was to investigate the effects of antioxidant N-acetylcysteine (NAC) and combined glutamine (Gln) on experimental colitis.Method:In order to achieve this, rats were randomized and administered intraperitoneal NAC or oral Gln + intraperitoneal NAC one day after experimental colitis model induced with trinitrobenzen sulphonic acid. After the treatment, the rats were sacrificed and colon damage was evaluated macroscopically and microscopically. Malonyldialdehyde level and superoxide dismutase activity were analyzed biochemically.Results:NAC and Gln + NAC groups showed macroscopically better results than the colitis group. Histopathologically, all treated groups provided significantly lower scores than the colitis group. Similarly, all treated groups provided better biochemical results than the colitis group.Conclusion:According to the results of the experiment, it was concluded that NAC had positive effects on experimental colitis model.