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We study the effect of anisotropy on holographic entanglement entropy (HEE) and holographic mutual information (MI) in the Q-lattice model, by exploring the HEE and MI for infinite strips along arbitrary directions. We find that the lattice always enhances the HEE. The MI, however, is enhanced by lattice for large sub-regions; while for small sub-regions, the MI is suppressed by the lattice. We also discuss how these phenomena result from the deformation of geometry caused by Q-lattices.