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Introduction: Strategic thinking is the infrastructure of artistic maneuvers of managers based on creativity and ‎true perception of business environments. It results in the creation of strategies suitable to the ‎present changing business environment. Due to the failure of strategic plans and organizational ‎changes in more than half of organizations, it can be concluded that there might be a common ‎cause for these failures. The goal of the present study was to assess the relationship between ‎readiness to change and strategic thinking in managers of social security hospitals of Isfahan, Iran, ‎based on the Liedtka model including the five elements of systemic thinking, intensive focus, ‎hypothesis approach, intelligent opportunism, and thinking in time. Methods: This practical, analytical, and correlative research was conducted using the Strategic Thinking ‎Assessment Questionnaire (α = 87.3) and Readiness to Dunhaim Change Assessment ‎Questionnaire (α = 84) in 2013. The participants consisted of 94 head, intermediate, and ‎operational managers of social security hospitals in Isfahan. Our response rate was 85% (80 ‎questionnaire). Data were analyzed using the Pearson correlation and regression analysis in SPSS ‎software. Results: Strategic thinking (Pearson coefficient = 0.25) (P < 0.02) and its elements based on the Liedtka ‎model, including systemic thinking (Pearson coefficient = 0.28) (P < 0.01), intensive focus (Pearson coefficient = 0.24) (P < 0.03), and intelligent opportunism (Pearson coefficient = 0.22) (P < 0.04), had a meaningful relationship with readiness to change. However, the findings ‎revealed no significant relationship between hypothesis approach (Pearson coefficient = 0.18) (P ‎‎< 0.01) and thinking in time (Pearson coefficient = 0.10) (P < 0.2), and readiness to change. Conclusion: Since there was an overall relationship between most elements of strategic thinking and readiness ‎to change among the managers in this study, education and development of strategic thinking may ‎enhance readiness to change among managers of institutions.