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Abstract We formulate the momentum-space Dokshitzer–Gribov–Lipatov-Altarelli–Parisi (DGLAP) evolution equations for structure functions measurable in deeply inelastic scattering. We construct a six-dimensional basis of structure functions that allows for a full three flavor structure and thereby provides a way to calculate perturbative predictions for physical cross sections directly without unobservable parton distribution functions (PDFs) and without the associated scheme dependence. We derive the DGLAP equations to first non-zero order in strong coupling $$\alpha _\textrm{s}$$ α s , but the approach can be pursued to arbitrary order in perturbation theory. We also numerically check our equations against the conventional PDF formulation.