Receptor-informed network control theory links LSD and psilocybin to a flattening of the brain’s control energy landscape
oleh: S. Parker Singleton, Andrea I. Luppi, Robin L. Carhart-Harris, Josephine Cruzat, Leor Roseman, David J. Nutt, Gustavo Deco, Morten L. Kringelbach, Emmanuel A. Stamatakis, Amy Kuceyeski
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-10-01 |
Deskripsi
There are several models of how serotonergic psychedelic drugs affect brain activity. Here the authors use network control theory and functional MRI data to provide evidence that serotonin receptor agonists LSD and psilocybin flatten the brain’s dynamic landscape, allowing for facile state transitions and more temporally diverse brain activity.